Tetrameric Chimera DK4mer is a Tool to Study Mechanisms Of Kinesin-5 Regulation. A Tetrameric Chimera of a Kinesin 1 and a Kinesin 5 is a Fast Microtubule Sliding Motor
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Kinesin-5 is a microtubule polymerase
Kinesin-5 slides antiparallel microtubules during spindle assembly, and regulates the branching of growing axons. Besides the mechanical activities enabled by its tetrameric configuration, the specific motor properties of kinesin-5 that underlie its cellular function remain unclear. Here by engineering a stable kinesin-5 dimer and reconstituting microtubule dynamics in vitro, we demonstrate tha...
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Kinesin-5, a widely conserved motor protein required for assembly of the bipolar mitotic spindle in eukaryotes, forms homotetramers with two pairs of motor domains positioned at opposite ends of a dumbbell-shaped molecule [1-3]. It has long been assumed that this configuration of motor domains is the basis of kinesin-5's ability to drive relative sliding of microtubules [2, 4, 5]. Recently, it ...
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The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is) administered in cell culture. However, cultured ce...
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1 Kinesin - 73 Is a Processive Motor That Localizes to Rab 5 - Containing Organelles
KINESIN-73 IS A PROCESSIVE MOTOR THAT LOCALIZES TO RAB5-CONTAINING ORGANELLES Thomas M. Huckaba, Arne Gennerich, James E. Wilhelm, Athar H. Chishti, and Ronald D. Vale Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158-2517, Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.892